The Governing Council of the institute shall be responsible for the overall administration of the Institute and to ensure that the objectives of the institute as set forth in the Memorandum of Association is being carried out.
| 1 | Hon’ble Chief Minister of Kerala | Chairperson |
| 2 | Hon’ble Minister for Health & Family Welfare, Govt. of Kerala | Vice Chairperson (Ex Officio) |
| 3 | Chief Secretary, Govt. of Kerala | Ex Officio Member |
| 4 | Secretary, Department of Biotechnology, Govt. of India | Ex Officio Member |
| 5 | Secretary, Department of Science and Technology, Govt. of India | Ex Officio Member |
| 6 | Director General, Indian Council of Medical Research, Govt. of India | Ex Officio Member |
| 7 | Additional Chief Secretary (Finance), Govt. of Kerala | Ex Officio Member |
| 8 | Principal Secretary, Science & Technology, Govt. of Kerala | Ex Officio Member |
| 9 | Principal Secretary (Health), Govt. of Kerala | Ex Officio Member |
| 10 | Secretary, Animal Husbandry, Govt. of Kerala | Ex Officio Member |
| 11 | Director, National Institute of Virology (NIV) Pune | Ex Officio Member |
| 12 | Director, Vector Control Research Centre, Puducherry | Ex Officio Member |
| 13 | Director, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram | Ex Officio Member |
| 14 | Director, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram | Ex Officio Member |
| 15 | Director, Health Services, Govt. of Kerala | Ex Officio Member |
| 16 | Director, Medical Education, Govt. of Kerala | Ex Officio Member |
| 17 | Chairperson, Research Advisory Committee, Institute of Advanced Virology | Ex Officio Member |
| 18 | Director, Institute of Advanced Virology (IAV) | Convenor (Member) |
Nominated Members:
| 1 | Dr. William Hall, Senior Advisor, IAV & Professor of School of Medicine, University College, Dublin | Member |
| 2 | Shri. M.C. Dathan, Mentor (Science), Govt. of Kerala & Former Director, VSSC Thiruvananthapuram | Member |
| 3 | Prof. M Radhakrishna Pillai, Former Director, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram | Member |
| 4 | Prof. Suresh Das, Emeritus Professor, Indian Institute of Science Education and Research (IISER), Thiruvananthapuram | Member |
| 5 | Prof S. MurtySrinivasula, Professor (Biology); Indian Institute of Science Education and Research (IISER), Thiruvananthapuram | Member |
| 6 | Dr.B.Ekbal, Former Member, Planning Board | Member |
| 7 | Dr. Jacob John, Retd. Professor, Clinical Virology, Christian Medical College, Vellore | Member |